Chondroitin sulfate

Chondroitin sulfate (CS) is a class of glycosaminoglycans covalently attached to proteins to form proteoglycans. Chondroitin sulfate is widely distributed in the extracellular matrix and cell surface of animal tissues. The sugar chain consists of alternating glucuronic acid and n-acetylgalactosamine (also known as n-acetylgalactosamine) disaccharide units, which are connected to serine residues of core proteins through a sugar-like linking region.

Although the main chain structure of polysaccharide is not complicated, it shows a high degree of heterogeneity in the degree of sulfation, the sulfate group and the distribution of the two differences to the isobaronic acid in the chain. The fine structure of chondroitin sulfate determines the functional specificity and the interaction with various protein molecules.

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